The Mexican fruit fly (Anastrepha ludens Loew), West India fruit fly (Anastrepha obliqua Macquart), guava fruit fly (Anastrepha striata Schiner) and sapote fruit fly (Anastrepha serpentina Wiedemann) are four economically significant native fruit fly species, due to their direct damages to crops and quarantine restrictions they cause to Mexican host commodities. To reduce the negative impact of these pests, integrated pest management is implemented with the aim to control, suppress and eradicate, (where it is possible due to the agro-ecological conditions and resources availability). As a result, the establishment and maintenance of free and low prevalence fruit fly areas facilitates the host commodity exportation. With this new fruit fly low prevalence zone, 506 hectares of mango orchards will be benefited, this represents an annual production of 4,000 ton and a monetary value of around USD 839,000.00. Through this fruit fly low prevalence zone agreement, Mexican Government recognize the localities of Aután, Chacalilla, El Capomo, El Carleño, El Culebra, El Limón, Guadalupe Victoria, Isla del Conde, La Chiripa, La Goma, Laureles Y Góngora, Madrigaleño, Pimientillo and Playa de Ramírez belonging to the San Blas Municipality in the State of Nayarit, Mexico, as a fruit fly low prevalence zone, which has been achieved due to the phytosanitary measures deployed.